A Geometric Interpretation for Local Alignment-Free Sequence Comparison
نویسندگان
چکیده
منابع مشابه
A Geometric Interpretation for Local Alignment-Free Sequence Comparison
Local alignment-free sequence comparison arises in the context of identifying similar segments of sequences that may not be alignable in the traditional sense. We propose a randomized approximation algorithm that is both accurate and efficient. We show that under D2 and its important variant [Formula: see text] as the similarity measure, local alignment-free comparison between a pair of sequenc...
متن کاملResearch Articles A Geometric Interpretation for Local Alignment-Free Sequence Comparison
Local alignment-free sequence comparison arises in the context of identifying similar segments of sequences that may not be alignable in the traditional sense. We propose a randomized approximation algorithm that is both accurate and efficient. We show that under D2 and its important variant D 2 as the similarity measure, local alignment-free comparison between a pair of sequences can be formul...
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MOTIVATION Alignment-free sequence comparison methods are still in the early stages of development compared to those of alignment-based sequence analysis. In this paper, we introduce a probabilistic measure of similarity between two biological sequences without alignment. The method is based on the concept of comparing the similarity/dissimilarity between two constructed Markov models. RESULT...
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ژورنال
عنوان ژورنال: Journal of Computational Biology
سال: 2013
ISSN: 1066-5277,1557-8666
DOI: 10.1089/cmb.2012.0280